Peroxynitrite is a key mediator of the cardioprotection afforded by ischemic postconditioning in vivo.
Myocardial ischemic postconditioning (PosC) describes an acquired resistance to lethal ischemia-reperfusion (I/R) injury afforded by brief episodes of I/R applied immediately after the ischemic insult.Cardioprotection is conveyed by parallel signaling pathways converging to prevent mitochondria permeability transition.Recent observations indicated